Here's the experiment. You start with a mess of a human, someone that is on the verge of total destruction of them self. Then through the science of hormonal therapy you create someone that is not only functional but is thriving in their new found happiness. Then, when their confidence is soaring, you take away all the things that they cling to for life and you sit back and see how long it takes for them to fall apart. Dr. Jekyll would be proud of the Ms. Hyde you've created!
Note: The rate and amount of destruction in test subject is in direct correlation with the amount of denial of hormones. Your mileage may vary!